Health●●●Banger
Design proteins from one formula, zero training data – runs in browser
Runs full protein folding physics in the browser using zero training data.
WizardryBig BrainNiche Gem
AlekseN
101mo ago
Back to browse
Conserved amino acid contacts across 70k protein structures
by xnullportx·Mar 5, 2026·1 point·0 comments
AI Analysis
●●SolidBig BrainNiche Gem
654k conserved interactions across 70k structures, but unclear what biologists do with it.
Strengths
- •Massive scale dataset (2460 families, 654k interactions) with rigorous statistical thresholds (PDBCon scoring)
- •Interactive explorer lets domain experts drill into families and fingerprints without coding
- •Clean data viz showing distribution by distance, useful for hypothesis formation
Weaknesses
- •No discussion of downstream use cases—what problems does this solve for wet labs or drug design?
- •Missing methodology paper or publication link validating the conservation thresholds
Category
Target Audience
Structural biologists, biochemists, computational biologists studying protein evolution
Similar To
Pfam · InterPro · RCSB PDB
Post Description
Thoughts?
Similar Projects
Health●●Solid
kg Food Log: Don't Track Calories; Track Molecules
Gemini-powered food inference with micronutrient detail, but missing verified nutrition data accuracy.
Solve My ProblemEye Candy
emadda
203mo ago
Productivity●●Solid
Payo – I got tired of losing contacts at conferences, so I built
12-second voice-to-contact flow beats awkward mid-conversation note-taking at events.
Solve My ProblemSlick
Raj7k
203mo ago
Data●●Solid
Numstore – a single file ACID database for NumPy arrays
ACID transactions for NumPy arrays when HDF5 and Zarr dominate the space.
Big BrainNiche Gem
lincketheo
2012d ago
Developer Tools●●Solid
Apple Contacts MCP – Local AI Access to macOS Contacts
Dry-run by default with confirmation phrases for deletes — actual safety thinking.
CozyNiche Gem
luwo
208d ago
Gaming●Mid
Beat Darwin
Wordle for animals with real iNaturalist data, but the format is well-worn.
CozyCrowd Pleaser
ecosystemj
102mo ago